Impaired cytoplasmic ionized calcium mobilization in inherited platelet secretion defects
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چکیده
منابع مشابه
Impaired cytoplasmic ionized calcium mobilization in inherited platelet secretion defects.
Defects in platelet cytoplasmic Ca++ mobilization have been postulated but not well demonstrated in patients with inherited platelet secretion defects. We describe studies in a 42-year-old white woman, referred for evaluation of easy bruising, and her 23-year-old son. In both subjects, aggregation and 14C-serotonin secretion responses in platelet-rich plasma (PRP) to adenosine diphosphate (ADP)...
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Platelet stimulation with ADP results in several responses. including shape change. increase in cytoplasmic ionized calcium concentration [Ca2 ],, and inhibition of adenylate cyclase. 5’-p-Fluorosulphonyb benzoybadenosine (FSBA), which covalently labels an ADP binding site on platelets. blocks platelet shape change but not the inhibition of cyclic AMP levels by ADP. whereas p-chloromercuribenze...
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We measured cytoplasmic ionized calcium concentrations [( Cai2+]) in aequorin-loaded gel-filtered platelets from 38 patients with acute occlusive stroke (12 treated with aspirin, 26 untreated) and 25 healthy controls. Compared with controls, baseline [Cai2+] was higher in untreated patients (p less than 0.002), maximal 36-72 hours after the onset of neurologic dysfunction (p less than 0.0001), ...
متن کاملADP-induced platelet shape change and mobilization of cytoplasmic ionized calcium are mediated by distinct binding sites on platelets: 5'-p-fluorosulfonylbenzoyladenosine is a weak platelet agonist.
Platelet stimulation with ADP results in several responses, including shape change, increase in cytoplasmic ionized calcium concentration [Ca2+]i, an inhibition of adenylate cyclase. 5'-p-Fluorosulphonyl benzoyladenosine (FSBA), which covalently labels an ADP binding site on platelets, blocks platelet shape change but not the inhibition of cyclic AMP levels by ADP, whereas p-chloromercuribenzen...
متن کاملPlatelet Shape Change and Mobilization of Cytoplasmic Ionized Calcium Are Mediated by Distinct Binding Sites on Platelets: 5’-p-Fluorosulfonylbenzoyladenosine Is a Weak Platelet Agonist
Platelet stimulation with ADP results in several responses. including shape change. increase in cytoplasmic ionized calcium concentration [Ca2 ],, and inhibition of adenylate cyclase. 5’-p-Fluorosulphonyb benzoybadenosine (FSBA), which covalently labels an ADP binding site on platelets. blocks platelet shape change but not the inhibition of cyclic AMP levels by ADP. whereas p-chloromercuribenze...
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ژورنال
عنوان ژورنال: Blood
سال: 1989
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v74.2.664.664